Rat Beta-Arrestin-1, ARRB1 ELISA Kit, 96T Protein Expression Hepatocyte growth factor-regulated tyrosine kinase

Hepatocyte growth factor-regulated tyrosine kinase substrate encoded by HGS regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors

Serine/threonine protein kinase which phosphorylates VIME

This gene encodes a tyrosine protein kinase

Multiple alternatively spliced transcript variants encoding the same protein are observed

Rat Beta-Arrestin-1, ARRB1 ELISA Kit, 96T Protein Expression Hepatocyte growth factor-regulated tyrosine kinaseFunctions in regulating agonist mediated G protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta arrestins bind to the GPRK phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta arrestins target