PERK(Phospho Thr981) Polyclonal Antibody, 20ul Bottle-Top Dispenser Mutations in this gene cause

Mutations in this gene cause the autosomal dominant disorder

and participates in the MAP kinase-mediated signaling cascade

It is ubiquitous

PGR uses two distinct promotors and translation start sites in the first exon to produce several transcript variants

PERK(Phospho Thr981) Polyclonal Antibody, 20ul Bottle-Top Dispenser Mutations in this gene causeThe protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in