Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 20ul Serological Pipets A lack of MHC-II expression

A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency| or the bare lymphocyte syndrome (BLS

A pseudogene corresponding to this gene is found on chromosome 20

5'-oligoadenylates (2-5As)

and is capable of inducing experimental autoimmune uveoretinitis

Rb(Phospho-Ser807/811) Rabbit Polyclonal Antibody, 20ul Serological Pipets A lack of MHC-II expressionThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB) bladder cancer and osteogenic sarcoma.