Cables1 Polyclonal Antibody, 100ul Micro Centrifuge Tubes The encoded protein contains a

The encoded protein contains a KRAB (Kruppel-associated box) domain -A box and a SET (Su(var)3-9| Enhancer-of-zeste| Trithorax) domain and may function as a histone methyltransferase

upstream open reading frame which is located between the GUG and the first AUG start codons

This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE)

These proteins bind and activate PDGF receptor tyrosine kinases

Cables1 Polyclonal Antibody, 100ul Micro Centrifuge Tubes The encoded protein contains aCABLES1 encodes a protein (Cdk5 and Abl enzyme substrate 1) involved in regulation of the cell cycle through interactions with several cyclin dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127). Multiple transcript variants encoding