P53 (Mono Methyl Lys370) Monoclonal Antibody(Q59), 100ul sgRNA Oligos The activity of the encoded

The activity of the encoded protein is regulated by polo-like kinase 1

probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases

The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding

Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon| and a downstream AUG codon| results in two isoforms

P53 (Mono Methyl Lys370) Monoclonal Antibody(Q59), 100ul sgRNA Oligos The activity of the encodedThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.