M4K5 Polyclonal Antibody, 100ul Reservoirs The type II hair keratins

The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity

This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1

Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage

LRP11 (low density lipoprotein receptor-related protein 11)

M4K5 Polyclonal Antibody, 100ul Reservoirs The type II hair keratinsThis gene encodes a member of the serine threonine protein kinase family, that is highly similar to yeast SPS1 STE20 kinase. Yeast SPS1 STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described