TM165 Rabbit Polyclonal Antibody, 50ul Cell Culture SLC22A18 is one of several

SLC22A18 is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15

Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex

The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex

and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases

TM165 Rabbit Polyclonal Antibody, 50ul Cell Culture SLC22A18 is one of severalThis gene encodes a predicted transmembrane protein with a perinuclear Golgi like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants.