Rb (Acetyl-K873/K874) Polyclonal Antibody, 50ul Pipette Filler There is a microRNA gene

There is a microRNA gene located within the 5' exon of this gene

This gene encodes a member of the PSCD family of proteins| which have an N-terminal coiled-coil motif| a central Sec7 domain| and a C-terminal pleckstrin homology (PH) domain

Alternatively spliced transcript variants have been found for this locus

The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD

Rb (Acetyl-K873/K874) Polyclonal Antibody, 50ul Pipette Filler There is a microRNA geneThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.