PLCB1 Polyclonal Antibody, 20ul Vector Construction disease:Defects in GRN are the

disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD)

This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family

and a C-terminal (C) domain

This gene has been linked to non-small cell lung cancer

PLCB1 Polyclonal Antibody, 20ul Vector Construction disease:Defects in GRN are theThe protein encoded by this gene catalyzes the formation of inositol 1,4,5 trisphosphate and diacylglycerol from phosphatidylinositol 4,5 bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G protein alpha subunits, alpha q and alpha 11. Two transcript variants encoding different isoforms have been found for this gene.