Ran BP-17 Polyclonal Antibody, 50ul Human Genome Knockout Libraries shows frequent overexpression in prostate

shows frequent overexpression in prostate and breast carcinomas

Two transcript variants encoding different isoforms have been found for CLEC6A

and inhibit E2F1-mediated transcription activity

This protein mediates the expression of a variety of genes in response to cell stimuli| and thus plays a key role in many cellular processes such as cell growth and apoptosis

Ran BP-17 Polyclonal Antibody, 50ul Human Genome Knockout Libraries shows frequent overexpression in prostateThe transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin alpha beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS dependent protein import. RAN binding protein 17 is a member of