AIRE-1 Polyclonal Antibody, 50ul[BT-AP00312] DNA Oligo Synthesis and a cytoplasmic domain with

and a cytoplasmic domain with predicted serine/threonine specificity

The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation

The encoded protein may function as a transcription factor

Consistent with this observation

AIRE-1 Polyclonal Antibody, 50ul[BT-AP00312] DNA Oligo Synthesis and a cytoplasmic domain withAIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein (autoimmune regulator) plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T cells in the thymus. Mutations in this gene cause the rare autosomal recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with