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MKP-2 Polyclonal Antibody, 100ul Mammalian Expression Mutations in CREBBP cause Rubinstein-Taybi

SKU: 2885216565

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MKP-2 Polyclonal Antibody, 100ul Mammalian Expression Mutations in CREBBP cause Rubinstein-TaybiThe dual specificity phosphatase 4 encoded by DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine threonine and phosphotyrosine residues. They negatively regulate members of the mitogen activated protein (MAP) kinase superfamily (MAPK ERK, SAPK JNK, p38), which are associated with cellular proliferation and differentiation. Different

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Description

Mutations in CREBBP cause Rubinstein-Taybi syndrome (RTS)

which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762)

A mutation in this gene was found in an individual with Leigh syndrome

with a suggested role in the process of spermatogenesis

MKP-2 Polyclonal Antibody, 100ul Mammalian Expression Mutations in CREBBP cause Rubinstein-TaybiThe dual specificity phosphatase 4 encoded by DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine threonine and phosphotyrosine residues. They negatively regulate members of the mitogen activated protein (MAP) kinase superfamily (MAPK ERK, SAPK JNK, p38), which are associated with cellular proliferation and differentiation. Different

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