GPR45 Polyclonal Antibody, 100ul Cell Culture Dishes Defects in this gene are

Defects in this gene are a cause of Wolfram syndrome 2

2002 [PubMed 12191433])

Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia

is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation

GPR45 Polyclonal Antibody, 100ul Cell Culture Dishes Defects in this gene areThis intronless gene encodes a member of the G protein coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.