SPTC2 Rabbit Polyclonal Antibody, 100ul Lysosome Three alternatively spliced transcript variants

Three alternatively spliced transcript variants have been described

An important paralog of this gene is GPR21

a disease characterized by recurrent bacterial infections

The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex

SPTC2 Rabbit Polyclonal Antibody, 100ul Lysosome Three alternatively spliced transcript variantsThis gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase which consists of two different subunits is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal 5 prime phosphate dependent condensation of L serine and palmitoyl CoA to 3 oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.