PTEN Monoclonal Antibody, 50ul Site-directed Mutagenesis PHF1 encodes a Polycomb group

PHF1 encodes a Polycomb group protein

The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells

and bind to the leukocyte adhesion LFA-1 protein

and over-expression of this gene is implicated in tumor growth and metastasis

PTEN Monoclonal Antibody, 50ul Site-directed Mutagenesis PHF1 encodes a Polycomb groupThis gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide