Rat Interleukin 10, IL-10 ELISA Kit, 96T Cell Senescence Activity of this protein is

Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6)

high level in activated lymphocytes and monocytes

PubMed: 16846591

but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase

Rat Interleukin 10, IL-10 ELISA Kit, 96T Cell Senescence Activity of this protein isMajor immune regulatory cytokine that acts on many cells of the immune system where it has profound anti inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2 mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti inflammatory mediators. Targets