p27(Phospho Thr198) Polyclonal Antibody, 50ul Petri Dishes Contains 5 C2 domains

Contains 5 C2 domains

(PMID: 20173098 ) From BLAST result

This gene originally was thought to be located at 17q21

The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate

p27(Phospho Thr198) Polyclonal Antibody, 50ul Petri Dishes Contains 5 C2 domainsThis gene encodes a cyclin dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A p21. The encoded protein binds to and prevents the activation of cyclin E CDK2 or cyclin D CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from