Human DNA Replication Factor Cdt1, CDT1 ELISA Kit, 96T Petri Dishes Diseases associated with PRDM12 include

Diseases associated with PRDM12 include neuropathy

It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation

It encodes a single-pass type I membrane protein with multiple cysteine rich domains| a transmembrane domain| a tyrosine kinase domain| a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC)

Human DNA Replication Factor Cdt1, CDT1 ELISA Kit, 96T Petri Dishes Diseases associated with PRDM12 includeRequired for both DNA replication and mitosis (PubMed: 11125146, PubMed: 22581055, PubMed: 21856198, PubMed: 14993212, PubMed: 26842564). DNA replication licensing factor, required for pre replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini chromosome maintenance (MCM) complex onto DNA to generate pre replication complexes (pre RC)(PubMed: