OLR1 Polyclonal Antibody, 100ul Immune Cell Analysis This gene is upregulated by

This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL

and involvement in cargo sorting during receptor endocytosis

Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED)

Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms

OLR1 Polyclonal Antibody, 100ul Immune Cell Analysis This gene is upregulated byThis gene encodes a low density lipoprotein receptor that belongs to the C type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low density lipoprotein. This protein may be involved in the regulation of Fas induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of