GRK 2(Phospho Ser685) Polyclonal Antibody, 20ul Sampling Tubes The protein encoded by TMEM185A

The protein encoded by TMEM185A (transmembrane protein 185A) is predicted to be a transmembrane protein

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is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988)

This gene encodes a member of the highly conserved cyclin C subfamily

GRK 2(Phospho Ser685) Polyclonal Antibody, 20ul Sampling Tubes The protein encoded by TMEM185AThe product of this gene phosphorylates the beta 2 adrenergic receptor and appears to mediate agonist specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta adrenergic and related G protein coupled receptors. Abnormal coupling of beta adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.