TDH Rabbit Polyclonal Antibody, 50ul Nucleic Acid Isolation & Purification Mutations in this gene cause

Mutations in this gene cause selective T-cell defect| a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M)

This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription

5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3)

TDH Rabbit Polyclonal Antibody, 50ul Nucleic Acid Isolation & Purification Mutations in this gene causeThis gene appears to be an evolving pseudogene of L threonine 3 dehydrogenase (TDH). In both prokaryotes and eukaryotes TDH catalyzes the first of two steps in one of two L threonine degradation pathways. However in human the single gene with sequence similarity to TDH is not capable of encoding a functional TDH protein; the predicted protein lacks most of the C terminus and parts of the NAD+ binding motif when compared to other species' TDH proteins.