GRK2(Phospho-Tyr86) Polyclonal Antibody, 100ul Antibody Humanization PubMed: 18503084

PubMed: 18503084

Cyclin F encoded by CCNF belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified

GO annotations related to this gene include calcium ion binding

Members of this family contain a single transmembrane domain

GRK2(Phospho-Tyr86) Polyclonal Antibody, 100ul Antibody Humanization PubMed: 18503084The product of this gene phosphorylates the beta 2 adrenergic receptor and appears to mediate agonist specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta adrenergic and related G protein coupled receptors. Abnormal coupling of beta adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.