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Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778

This isoform is identified as an autoantigen in 66% of patients with Felty syndrome

The coordinated degradation of Dbf4 and the time of chromosomes separation is important to ensuring that prereplicative complexes

CD32 Polyclonal Antibody, 20ul[BT-AP07393] Aspirating Pipets Take the risk and experienceThe Fc fragment of IgG receptor IIb encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.