ST5 Polyclonal Antibody, 100ul Aspirating Pipets The TRIM motif includes zinc-binding

The TRIM motif includes zinc-binding domains| a RING finger region| a B-box motif and a coiled-coil domain

RNA interference (RNAi) is a powerful gene silencing tool

This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol| a precursor of phosphatidylinositol| and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1|4|5-trisphosphate and diacylglycerol

and is imprinted and expressed from the paternal allele

ST5 Polyclonal Antibody, 100ul Aspirating Pipets The TRIM motif includes zinc-bindingST5 was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. Suppression of tumorigenicity 5 protein encoded by ST5 contains a C terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c Abl kinase, and acts as a regulator of MAPK1 ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three