PP4R2 Polyclonal Antibody, 100ul Immunoassays Defects in MEGF8 are a

Defects in MEGF8 are a cause of Carpenter syndrome 2

Three alternative splice variants| each of which encodes a different isoform| have been identified

These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes

This gene encodes a clathrin assembly protein

PP4R2 Polyclonal Antibody, 100ul Immunoassays Defects in MEGF8 are aSerine threonine protein phosphatase 4 regulatory subunit 2 encoded by PPP4R2 is a regulatory subunit of the serine threonine protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene.