SENP5 Polyclonal Antibody, 50ul 3D Culture disease:Defects in CD40LG are the

disease:Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1)

The fucosyltransferase 2 encoded by FUT2 is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen

and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins

Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication

SENP5 Polyclonal Antibody, 50ul 3D Culture disease:Defects in CD40LG are theThe reversible posttranslational modification of proteins by the addition of small ubiquitin like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO