Bovine Caspase 3, CASP3 ELISA Kit , 96T Supplements Plays a critical role in

Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress

The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene

two paralogs of the yeast protein have been identified

and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7)

Bovine Caspase 3, CASP3 ELISA Kit , 96T Supplements Plays a critical role inInvolved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP ribose) polymerase (PARP) at a '216 Asp Gly 217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix loop helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase 6, 7 and 9. Involved in the cleavage of huntingtin.