Mdm2 Polyclonal Antibody, 100ul[BT-AP05302] Thermal Control Members of the CELF/BRUNOL protein

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains

and mutations in SLC1A1 are thought to cause dicarboxylicamino aciduria

This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus

AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains

Mdm2 Polyclonal Antibody, 100ul[BT-AP05302] Thermal Control Members of the CELF/BRUNOL proteinMDM2 encodes a nuclear localized E3 ubiquitin ligase. E3 ubiquitin protein ligase Mdm2 can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript