PDX-1 Polyclonal Antibody, 50ul Site-directed Mutagenesis EF-hand calcium binding domain 5)

EF-hand calcium binding domain 5) is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes

while defects in this gene are associated with multiple types of cancer

it ensures optimal cell growth and viability

A chromosomal translocation that includes this gene is associated with Peters' anomaly

PDX-1 Polyclonal Antibody, 50ul Site-directed Mutagenesis EF-hand calcium binding domain 5)The protein encoded by PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early onset insulin dependent