Endothelin B Receptor Polyclonal Antibody, 50ul Primary Antibodies Mutations associated with this gene

Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4

TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity

As the sequence environment of the 2 potential ATG initiator codons is the same for the other altrnatively spliced isoforms| alternative initiation of translation could also occur on these transcripts

SH3 domains

Endothelin B Receptor Polyclonal Antibody, 50ul Primary Antibodies Mutations associated with this geneThe protein encoded by this gene is a G protein coupled receptor which activates a phosphatidylinositol calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple