HBG1 Rabbit Polyclonal Antibody, 50ul Serum & Sample Tubes Defects in ferritin proteins are

Defects in ferritin proteins are associated with several neurodegenerative diseases

The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members

Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1

SIGLEC5 encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family

HBG1 Rabbit Polyclonal Antibody, 50ul Serum & Sample Tubes Defects in ferritin proteins areThe gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta thalassemias and related conditions gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G gamma product (HBG2)