Rb(Phospho Ser795) Polyclonal Antibody, 50ul Syringe Filter Ataxin-2-like protein is a member

Ataxin-2-like protein is a member of the spinocerebellar ataxia (SCAs) family

Additional alternatively spliced transcript variants of DYRK4 have been described

Pseudogenes have been identified on chromosomes 2 and 12

Both proteins bind the p53 tumor suppressor protein and inhibit its activity

Rb(Phospho Ser795) Polyclonal Antibody, 50ul Syringe Filter Ataxin-2-like protein is a memberThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.