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Caspase12 Polyclonal Antibody, 50ul miRNA / siRNA Synthesis PBK (PDZ binding kinase) encodes

SKU: 51657764573

4.4
EUR185.00 EUR229.00

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Caspase12 Polyclonal Antibody, 50ul miRNA / siRNA Synthesis PBK (PDZ binding kinase) encodesCaspases are cysteine proteases that cleave C terminal aspartic acid residues on their substrate molecules. CASP12 is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of CASP12 mediates apoptosis in response to endoplasmic reticulum stress. However, in humans CASP12 contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals

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Description

PBK (PDZ binding kinase) encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family

The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles

The encoded protein downregulates apoptosis signal-regulating kinase 1

there is a partial or complete deletion of this region from the paternal copy of chromosome 15

Caspase12 Polyclonal Antibody, 50ul miRNA / siRNA Synthesis PBK (PDZ binding kinase) encodesCaspases are cysteine proteases that cleave C terminal aspartic acid residues on their substrate molecules. CASP12 is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of CASP12 mediates apoptosis in response to endoplasmic reticulum stress. However, in humans CASP12 contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals

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