MSH2 Monoclonal Antibody, 50ul Cellular Cultivation & Health Management Ral (see MIM 179550)

Ral (see MIM 179550)

which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits

later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654

A similar protein in fly functions as a tumor suppressor

MSH2 Monoclonal Antibody, 50ul Cellular Cultivation & Health Management Ral (see MIM 179550)This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.