Dkk-1 Polyclonal Antibody, 50ul Funnels The protein encoded by ARHGEF2

The protein encoded by ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2)may form complex with G proteins and stimulate rho-dependent signals

by proteolytic processing

and that loss of this protection results in cell death and sensorineural hearing loss

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain

Dkk-1 Polyclonal Antibody, 50ul Funnels The protein encoded by ARHGEF2DKK1 encodes dickkopf WNT signaling pathway inhibitor 1 that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.