DEN1B Rabbit Polyclonal Antibody, 50ul Proteases In nonmuscle cells| the cytoskeletal

In nonmuscle cells| the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions| where it is involved in binding actin to the membrane

Proteins expressed using the baculovirus-insect expression system retain full biological functionality and can accommodate larger exogenous fragments

The plate is transparent with excellent optical properties and is easy to observe under a microscope

This gene encodes a member of the membrane-spanning 4A gene family| members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues

DEN1B Rabbit Polyclonal Antibody, 50ul Proteases In nonmuscle cells| the cytoskeletalClathrin (see MIM 118955) mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family such as DENND1B function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein 2 (AP2; see MIM 601024). Thus connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson 2010