TELT Polyclonal Antibody, 100ul Deep Well Plates Knockout studies in mice suggest

Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macro

Other genes in the cluster include those encoding interleukins 4

Mutations in this gene contribute to mitochondrial complex 1 deficiency

and dysregulation of Ras signaling has been associated with many types of cancer

TELT Polyclonal Antibody, 100ul Deep Well Plates Knockout studies in mice suggestSarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1 Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly.