Human Securin, PTTG1 ELISA Kit , 96T Human Genome Knockout Libraries suggesting a role as a

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Human Securin, PTTG1 ELISA Kit , 96T Human Genome Knockout Libraries suggesting a role as aRegulatory protein, which plays a central role in chromosome stability, in the p53 TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however

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