MerTK Polyclonal Antibody, 100ul Centrifugal Filter The protein is anchored to

The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells

but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase

BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis

The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding

MerTK Polyclonal Antibody, 100ul Centrifugal Filter The protein is anchored toMERTK is a member of the MER AXL TYRO3 receptor kinase family and encodes a transmembrane protein, tyrosine protein kinase mer, with two fibronectin type III domains, two Ig like C2 type (immunoglobulin like) domains, and one tyrosine kinase domain. Mutations in MERTK have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).