HLA-DOBeta Polyclonal Antibody, 50ul Variant Libraries is associated with mutations in
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HLA-DOBeta Polyclonal Antibody, 50ul Variant Libraries is associated with mutations inHLA DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26 28
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