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CAMLG Polyclonal Antibody, 20ul Endonucleases & Exonucleases This protein transports low-density lipoproteins

SKU: 62335004504

4.5
PLN97.20 PLN138.20

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CAMLG Polyclonal Antibody, 20ul Endonucleases & Exonucleases This protein transports low-density lipoproteinsThe immunosuppressant drug cyclosporin A blocks a calcium dependent signal from the T cell receptor (TCR) that normally leads to T cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This

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Description

This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol

Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778

CCL4L1 is one of several cytokine genes that are clustered on the q-arm of chromosome 17

which plays a role in bone

CAMLG Polyclonal Antibody, 20ul Endonucleases & Exonucleases This protein transports low-density lipoproteinsThe immunosuppressant drug cyclosporin A blocks a calcium dependent signal from the T cell receptor (TCR) that normally leads to T cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This

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