Paxillin Polyclonal Antibody, 100ul[BT-AP06956] Cell Labeling & Imaging The homodimers and heterodimers compete

The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation

encoding nearly 900 genes

Mutations in LMNA lead to several diseases: emery-Dreifuss muscular dystrophy

Crohn's disease and inflammatory bowel disease

Paxillin Polyclonal Antibody, 100ul[BT-AP06956] Cell Labeling & Imaging The homodimers and heterodimers competePXN encodes a cytoskeletal protein involved in actin membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for PXN. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties.