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Rent1 Polyclonal Antibody, 50ul Serum Mutations in this gene are

SKU: 6526809343

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Rent1 Polyclonal Antibody, 50ul Serum Mutations in this gene areUPF1 (UPF1, RNA helicase and ATPase) encodes a protein that is part of a post splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense mediated mRNA decay (NMD). When translation ends upstream from the last exon exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located

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Description

Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance

Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function

It is composed of three C2H2-type zinc-fingers

Altered expression of NAD(P)H quinone dehydrogenase 1 has been seen in many tumors and is also associated with Alzheimer's disease (AD)

Rent1 Polyclonal Antibody, 50ul Serum Mutations in this gene areUPF1 (UPF1, RNA helicase and ATPase) encodes a protein that is part of a post splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense mediated mRNA decay (NMD). When translation ends upstream from the last exon exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located

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