SREBP-1 Polyclonal Antibody, 50ul[BT-AP08552] Apoptosis & Autophagy 2010 [PubMed: 20933441])

2010 [PubMed: 20933441])

It plays a negative regulatory role in the Ras-Raf1-MAPK pathway

Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes

The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis

SREBP-1 Polyclonal Antibody, 50ul[BT-AP08552] Apoptosis & Autophagy 2010 [PubMed: 20933441])SREBF1 encodes a transcription factor that binds to the sterol regulatory element 1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. Sterol regulatory element binding protein 1 is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by