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Rb(Phospho Ser608) Polyclonal Antibody, 50ul Biomatrix Seems to play an essential

SKU: 68918328380

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Rb(Phospho Ser608) Polyclonal Antibody, 50ul Biomatrix Seems to play an essentialThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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Description

Seems to play an essential role in cold-induced suppression of cell proliferation

Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma

C1r is a single-chain glycoprotein which can be cleaved into an A chain and a B chain upon activation

EWSR1 on chromosome 22

Rb(Phospho Ser608) Polyclonal Antibody, 50ul Biomatrix Seems to play an essentialThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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