RFWD3 Polyclonal Antibody, 50ul Thermo Mix A human melanoma-associated chondroitin sulfate

A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes

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They participate in two different transcriptional regulation processes

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RFWD3 Polyclonal Antibody, 50ul Thermo Mix A human melanoma-associated chondroitin sulfateRFWD3, also named as RNF201, is a E3 ubiquitin protein ligase that mediates the ubiquitination of p53 TP53 in the late response to DNA damage, and acts as a positive regulator of p53 TP53 stability, thereby regulating the G1 S DNA damage checkpoint. RFWD3 may act by catalyzing the formation of short polyubiquitin chains on p53 TP53 that are not targeted to the proteasome. In response to ionizing radiation, It interacts with MDM2 and enhances p53 TP53