SIGIR Polyclonal Antibody, 20ul Filtration May play a role in

May play a role in cell proliferation of NT2 embryonal carcinoma cells

and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma

but our experiment always detected a 60-70kDa protein by western blot

Activated by phosphorylation at Thr-838| inhibited by phosphorylation at Ser-966 and Ser-1033

SIGIR Polyclonal Antibody, 20ul Filtration May play a role inActs as a negative regulator of the Toll like and IL 1R receptor signaling pathways. Attenuates the recruitment of receptor proximal signaling components to the TLR4 receptor, probably through an TIR TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.,Belongs to the interleukin 1 receptor family.,Contains 1 Ig like C2 type (immunoglobulin like) domain.,Contains 1 TIR