MAGI-2 Polyclonal Antibody, 50ul DNA Synthesis suggesting that down-regulation is the

suggesting that down-regulation is the result of methylation of the gene

The DNA-binding activity may reside exclusively on the 70 kDa subunit

designated the Sec insertion sequence (SECIS) element

tissue specificity:Expressed in kidney

MAGI-2 Polyclonal Antibody, 50ul DNA Synthesis suggesting that down-regulation is theThe protein encoded by MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2)interacts with atrophin 1. Atrophin 1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase like domain, and multiple PDZ domains. It has structural similarity to the membrane associated guanylate kinase homologue (MAGUK)