HXD9 Polyclonal Antibody, 100ul Low-speed Centrifuges this loss is due to

this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation

A mutation in this gene was associated with mental retardation

This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor

the encoded protein may increase the viability of certain cell types through modulation of p53 activity

HXD9 Polyclonal Antibody, 100ul Low-speed Centrifuges this loss is due toThis gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31 2q37 chromosome regions.