MSH2 Monoclonal Antibody, 100ul Sampling Tubes Multiple transcript variants encoding several

Multiple transcript variants encoding several different isoforms have been found for ZMYND8

In response to DNA damage and replication blocks| cell cycle progression is halted through the control of critical cell cycle regulators

The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units

Three protein-coding and one non-coding transcript variant have been found for this gene

MSH2 Monoclonal Antibody, 100ul Sampling Tubes Multiple transcript variants encoding severalThis locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.